Tuesday, October 28, 2008

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fitness - Antioxidants, Diet and Cancer



Antioxidants, Diet and Cancer



Cancer is on the rise. In 1988, the Surgeon General estimated that an American born in 1985 has a 30 percent chance of dying from this disease. This figure doesn't take into account the individuals who will get cancer and survive. Cancer is a slowing growing disease (actually group of diseases) egged on by the cumulative effects of cancer promoting substances and activities. At least 80 percent of cancers are caused by lifestyle habits, including diet. Fortunately, diet, especially one rich in antioxidants, can protect you against cancer.



In the fall of 1989, a group of scientists from around the world met in London to talk about antioxidants. Everyday, normal metabolic processes as well as environmental pollutants, tobacco smoke, and rancid fats create highly reactive molecules called free radicals. Free radicals damage cells and may impede health. During their three day meeting, researchers reviewed the evidence and discovered that antioxidants reduce free radical damage and possibly cancer.



Antioxidants come in a variety of forms. Plants are a plentiful and powerful source of antioxidants in part because these botanicals often have an affinity for particular organs. For example, the antioxidant acting flavonoids in milk thistle target the liver. Those in ginkgo are attracted to the central nervous system, including the brain. Probably the most well known plant antioxidants are carotenoids, the yellow pigment found in many fruits and vegetables.



In addition, antioxidants can include vitamins such as C, E, and A, and minerals like selenium, zinc, copper, and manganese. Here are some of the findings from the London conference on a fraction of the antioxidants available to us.



Eat Your Fruits and Vegetables

The echo of motherly advice, "eat your vegetables", is now being heard in scientific laboratories. In a paper presented by the National Cancer Institute, Regina Ziegler reviewed the relationship between vegetable, fruit and carotenoid intake, and cancer rates. Of the many hundreds of carotenoids found in our food--primarily fruits and vegetables--many are antioxidants. Beta-carotene is the most abundant and well known carotenoid.



Ziegler found a definite link between fruits and vegetables in the diet, and cancer. The strongest relationship was for lung cancer, although cancer of the stomach, cervix, neck, breast, and bladder were also reported. However, some of the studies Ziegler analyzed lasted for only five years. Considering that cancer may take 20 or more years to develop, the association between vegetables and cancer may be even stronger. Ziegler also admits that when you eat your fruit and vegetables, fiber and other antioxidants such as vitamin C may also protect against cancer.



Although we don't know all the ins and outs of the vegetable-cancer connection, there is, without a doubt, a benefit. It is sad that most Americans neglect this portion of their diet. The Second National Health and Nutrition Examination Survey revealed that only 10 percent of the 12,000 adults it surveyed ate the recommended five servings of fruits and vegetables each day. fitness - Article

Fat Chance: Do Dietary Guidelines Actually Contribute to Obesity?

In this episode, Albert Einstein College of Medicine public health researcher Paul Marantz questions whether dietary guidelines are counterproductive and talks about the philosophy of recommendations based on population studies. We'll hear a Valentine's Day poem. Plus we'll test your knowledge of some recent science in the news. Websites mentioned on this episode include sciammind.com, sciamdigital.com, snipurl.com/sing-sciam, snipurl.com/paul-sciam, snipurl.com/paul2-sciam, snipurl.com/paul3-sciam

Welcome to Science Talk, the weekly podcast of Scientific American for the seven days starting February 13th, 2008. I'm Steve Mirsky. This week: a chat with epidemiologist, Paul Marantz, about how studies on lots of people's lifestyles lead to health recommendations and medical interventions. We'll have a Valentine's Day poem from a listener, plus we'll test your knowledge about some recent science in the news. Paul Marantz is professor of Clinical Epidemiology and Population Health at the Albert Einstein College of Medicine in New York City. He and colleagues recently published a controversial paper in the American Journal of Preventive Medicine. On Monday morning, February 11th, we talked in his Einstein office about the article and about the philosophy behind recommendations based on studies.



Steve: Dr. Marantz, good to talk to you today.



Marantz: Hi, Steve.



Steve: Very interesting paper you have here, "A Call for Higher Standards of Evidence for Dietary Guidelines." Let's cut right to the quick and then we'll back up a bit; but your basic thesis is?



Marantz: Our basic thesis is that the standards that had been applied to determining and promulgating dietary guidelines for all Americans have been insufficient to protect against the possibility of harm and in fact our analysis suggest that there indeed may be harm that can be an outcome of these guidelines. And once that's considered, the issue of standards of evidence becomes much more pressing.



Steve: And specifically, you're talking about the dietary guidelines about fat, as an example.



Marantz: That's the example we focus on. I think, the general concept of dietary guidelines is one that we explore, because we were curious as to why we then are in this business? Or why [is] the government is in this business? So by analyzing and focusing on the dietary fat guidelines, which we are not the first to do, others Gary Taubes and others have made that point in the lay press, and it has been in their professional literature as well, but we provided another data analysis consistent with the notion that focusing on fat led Americans to eat more calories overall, [and] has contributed to our obesity epidemic. And in light of that evidence, we really should be extremely cautious and careful when issuing guidelines.



Steve: Right. So the specific point that's controversial is that the dietary guidelines that were put into effect by the government in an effort to get people to cut down on their fat intake actually contributed to the obesity epidemic, and you point out this [out], you know, its very simple math-people did cut down on their fat calories as a percentage of total calories by increasing their total calories.



Marantz: That's it. Yeah, you can change the percentage or the proportion in two ways. You can reduce the numerator-how much fat people eat in total-which was clearly the goal of these guidelines; or you can also get the same effect proportionately by increasing the denominator-how much total calories you eat, I mean the total calories you eat.



Steve: Right. So now you have people [saying], "Well, I have cut my fat percentage down to below the 30 percent that the government recommended," but they are eating 3,000 calories a day, instead of 2,500.



Marantz: We can all remember, and in fact we still do, wolf down these low fat snacks that seem to us to be healthful or safe because we were really all taught that if the food was low fat it was healthful-that was the inference that we were led to make. By the way, this is not ancient history, the first official published dietary guidelines for all Americans were published in 1980, and it is now a legal mandate that they have to be reissued every five years. You know, reevaluate the evidence as it's done and reassure the guidelines. Then the focus was on cardiovascular disease, so a single-minded focus or at least a primary focus on dietary fat made sense with a cholesterol hypothesis. And of course we weren't focusing on total calories, we were focusing on dietary fat. The irony is, now that we have the obesity epidemic, suddenly calories have become the issue.



Steve: Go back a little bit to the idea of dietary guidelines. You point out in the paper, [the] government first issued nutritional guidelines in 1894, but these dietary guidelines as you say are kind of new. The original guidelines-well why don't you explain the difference?



Marantz: Well, they made great sense in the turn of the century when public health professionals were trying to meet the mission of public health, which is defined as assuring conditions in which the public can be healthy-that's how public health is defined. And in a time when malnutrition was a problem and, the emergence of nutritional science was helping public health professionals understand what needed to be in the diet in order for people to be healthy, to avoid deficiencies. It made good sense to issue information about the way in which vitamin C can prevent scurvy and that sort of stuff and that's where I guess, the minimum daily requirements came from. Over the 20th century, we did see our nutritional concerns move from issues of deficiency to issues of excess; and in that shift we saw a focus instead on the sorts of problems that excess leads: to coronary artery disease, diabetes, obesity, those sorts of concerns.



Steve: In your paper, you discuss something that doesn't get really talked about too much among lay people and that's one of the key, kind of, philosophical foundations of epidemiological studies and policy recommendations and that's this idea of small changes in risk for individuals winding up making large changes in outcomes in populations. That's something that really informs a lot of the decision making. So let's talk about, you know, what we see it in a cutback on your salt if you have hypertension and in the dietary guidelines, too, with cholesterol levels and diet. So let's talk about that a little bit, this idea of little changes for people making big changes in populations. One small step for a man, one giant leap for mankind!

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Biden Is Healthy, Medical Records Show

Mon, 20 Oct 2008 18:05:26 EST
Medical records released by the Obama-Biden campaign suggest that vice presidential candidate Joe Biden is in good health, according to press reports.

Google Earth for iPhone Surfs the World by Gestures Featured IPhone Download]

Mon, 27 Oct 2008 05:30:00 PDT

iPhone/iPod touch 2.0 only: Google has released an official Google Earth client for the iPhone and iPod touch, giving your phone a slide-and-pinch view of the world. There are only two layers at this moment—geo-located Wikipedia articles and Panoramio photos—and, as you might imagine, the app is a bit of a data hound and best used on a Wi-Fi connection. Having said that, though, there's something irrepressibly cool about swiping your way around your neighborhood, tiling your phone to angle and scope the terrain, and using your device's current location finder to zoom down on yourself from space. Google Earth is a free download for iPhones and iPod touch models running the 2.0 software upgrade only.










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